Retinols: stimulate cell turnover, improve texture, target acne, and boost collagen

Retinol is that overarching friend who does everything: smooths fine lines, brightens dullness, fades pigmentation, prevents breakouts, and stimulates collagen production. Derived from Vitamin A, it’s one of the most studied and trusted ingredients in skincare—and for good reason.

That said, retinols can be tricky. Not all retinoids are created equal. Too much, too fast, or the wrong formulation can leave you irritated, flaky, or sensitized. The key is not just which one you choose—but how you use it. This is a marathon ingredient, not a sprint.

Types to Know:

• Retinol (OTC) – gentler, more widely available, and ideal for beginners or sensitive skin
• Retinaldehyde – a step closer to prescription strength, with better tolerability for many
• Tretinoin (Rx) – the prescription-grade powerhouse, excellent for acne and aging
• Hydroxypinacolone Retinoate (HPR) – a newer, less irritating retinoid that doesn’t need conversion

Note: Bakuchiol is a plant-based alternative to retinol even safe for my pregnant mamas.

Favorites in the category:

• SkinBetter Science AlphaRet Overnight Cream
  A cult favorite for a reason. This combines a gentle retinoid with lactic acid, delivering results without the traditional irritation. It’s a perfect option for retinol beginners or those with sensitive skin.
• ZO Skin Health Retinol Skin Brightener, Wrinkle + Texture Repair, or Radical Night Repair
  ZO doesn’t mess around with their retinols. These products are heavy hitters in brightening, firming, and refining skin. Expect flaking (aka “the retinol glow-up”), but the long-term payoff is smoother, clearer, tighter skin. Ideal for those ready to level up.
• Prescriptive Tretinoin (aka Retin-A)
  Still the gold standard for acne and aging. Available in various strengths and best used under the guidance of a provider. Read the prescription section for more on this!
• Epionce Lytic Tx (there are 4 strengths)
  Technically not a retinoid, but a clinically-backed alternative that exfoliates, clears congestion, and improves texture with much less risk of irritation. A longtime favorite for oily, acne-prone skin.
• Medi8 Bakuchiol Peptides
  An option for those avoiding retinoids—especially pregnant/breastfeeding moms. It mimics many of the benefits of retinol (think: smoother texture, brighter skin, fewer breakouts) without the irritation or restrictions.

Pro Tips:

• Use retinol at night only—sunlight breaks it down.
• Start 2–3 nights a week, then increase as tolerated.
• Always pair with SPF and a barrier-repairing moisturizer.
• Skip mixing with strong exfoliants or acne treatments unless you know your skin can handle it.